Boc-(2S,4S)-4-fluoro-pyrrolidine-2-carboxylic acid, Boc-flp-OH

Name	(2S,4S)-4-Fluoro-N-Boc-Pyrrolidine-2-carboxylic acid
Synonyms	Boc-cis-4-fluoro-Pro-OH Boc-cis-L-4-Fluoroproline N-BOC-cis-4-fluoro-L-proline N-t-BOC-cis-4-Fluoro-L-proline (2S,4S)-N-Boc-cis-4-Fluoro-L-proline cis-4-Fluoro-L-proline, N-BOC protected (4S)-1-(tert-butoxycarbonyl)-4-fluoro-L-proline (2S,4S)-Boc-4-fluoro-pyrrolidine-2-carboxylic acid (2S,4S)-N-Boc-4-fluoropyrrolidine-2-carboxy lic acid (2S,4S)-4-Fluoro-N-Boc-Pyrrolidine-2-carboxylic acid Boc-(2S,4S)-4-fluoro-pyrrolidine-2-carboxylic acid, Boc-flp-OH (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid, N-BOC protected 4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid (2S,4S)-4-Fluoro-1-tert-butoxycarbonyl-pyrrolidine-2-carboxylic acid (2S,4S)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid N-(tert-Butoxycarbonyl)-cis-4-fluoro-L-proline N-Boc-cis-4-fluoro-L-proline
CAS	203866-13-1
InChI	InChI=1/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m0/s1
InChIKey	YGWZXQOYEBWUTH-BQBZGAKWSA-N

Molecular Formula	C10H16FNO4
Molar Mass	233.24
Density	1.24±0.1 g/cm3(Predicted)
Melting Point	157-161.°C
Boling Point	346.0±42.0 °C(Predicted)
Flash Point	163°C
Vapor Presure	1.05E-05mmHg at 25°C
Appearance	Solid
pKa	3.53±0.40(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	-57 ° (C=1, MeOH)
MDL	MFCD04973957

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29339900
Hazard Class	IRRITANT

introduction	(2S,4S)-N-Boc-cis -4-fluorine-L-proline is solid at normal temperature and pressure,(2S,4S)-N-Boc-cis -4-fluorine-L-proline is an amino acid derivative of proline series, it is widely used in the synthesis of biological macromolecules and bioactive molecules.
use	(2S,4S)-N-Boc-cis -4-fluorine-L-proline is an amino acid derivative of proline series and has a wide range of applications in the synthesis of biological macromolecules. In the synthetic transformation, the carboxyl group in the structure can become a hydroxyl group under the reduction of borane, and the Boc group is not affected during the reduction process; in addition, the carboxyl group can also be converted into an amide group.
preparation method	at room temperature, to 2-methyl (2S,4S)-4-fluoropyrrolidine -1, 2-dicarboxylic acid tert-butyl ester (2.46g, 9.96 mmol) 10ml of water was added to a solution of dioxane (20 ml), then lithium hydroxide hydrate (2.09g, 49.8 mmol) was added slowly, and the resulting mixture was reacted with stirring for 3 hours (monitored by TLC). After the reaction is over, filter the solution to remove insoluble substances, evaporate the obtained filtrate in vacuum to remove the solvent, add the residue to 10mL of water, acidify the residue to pH 3-4 with concentrated hydrochloric acid, and slowly precipitate, filter and dry the solid precipitate to obtain the target product (2S,4S)-N-Boc-cis -4-fluorine-L-proline. Figure (2S,4S)-Synthesis route of N-Boc-cis-4-fluoro-L-proline

Last Update：2024-04-09 01:59:58

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CAS: 203866-13-1
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Boc-(2S,4S)-4-fluoro-pyrrolidine-2-carboxylic acid, Boc-flp-OH Request for Quotation